The participation of opiatergic mechanisms in the regulation of bone marrow hematopoiesis in stress
Zakharova, O.I.; Dygaĭ, A.M.; Shakhov, V.P.; Gol'dberg, E.D.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 6: 11-14
1989
ISSN/ISBN: 0031-2991 PMID: 2560826 Document Number: 346178
It is shown that immobilization stress intensifies functional activity of hematopoietic precursor cells, which leads to the development of medullary hyperplasia. Injection of dalargin into immobilized animals as well as its addition to the culture medium in producing clones of myelokaryocytes derived from donors subjected to stress in vitro reduces the colony- and cluster-forming activity of bone marrow cells and causes suppression of erythro- and granulocytopoiesis. Naloxone abolishes the suppressive effect of dalargin in vivo and in vitro but at the same time attenuates bone marrow hyperplasia in stress. It is suggested that naloxone may block both the stimulating and the inhibiting effect of enkephalins on hematopoiesis in stress.