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Agranulocytosis--a complication of the chemotherapy of echinococcosis with mebendazole

Shcherbakov, A.M.; Kozlova, T.L.; Bebris, N.K.

Meditsinskaia Parazitologiia i Parazitarnye Bolezni 1992(5-6): 9-11

1992

ISSN/ISBN: 0025-8326
PMID: 1299770
Document Number: 400294
Only two of the 75 patients with echinococcosis, treated with mebendazole in a dose of 50 mg/kg b. m. for 30 days (single course) and administered from 1 to 13 courses with intervals of 1 to 3 months, developed agranulocytosis eventuating in death in one female patient. Analysis of blood levels of mebendazole and its metabolites permits a hypothesis that high concentrations thereof may have a toxic effect on the bone marrow, inducing its hypoplasia, in subjects sensitive to these substances.

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