Alcohol and atherogenesis: effect of low and high doses of ethanol on rat blood cholesterol
Bozhko, G.K.; Chursina, V.S.; Voloshin, P.V.
Voprosy Meditsinskoi Khimii 38(2): 44-47
1992
ISSN/ISBN: 0042-8809 PMID: 1413632 Document Number: 399598
Alterations in content of cholesterol and specific radio-activity of erythrocyte lipoproteins were studied in rats after administration of labelled sterol under conditions of acute and chronic influence of low 0.6 g/kg and high 4.0 g/kg doses of ethanol. Both these doses caused a decrease in content of high density lipoproteins (HDL) after single ethanol administration, while content of apoB containing lipoproteins as well as binding of labelled sterol with erythrocytes were elevated after long-term ethanol treatment. Atherogenicity index was increased after single and chronic administration of either low or high doses of ethanol. In chronic administration of low doses of ethanol specific radioactivity of HDL was decreased, thus suggesting that cholesterol acceptor function of these particles was lowered.