Activation of free radicals reaction and changes in the state of antioxidant protection in blood in toxic experimental influenza infection
Gorbunov, N.V.; Volgarev, A.P.; Braĭlovskaia, I.V.; Bykova, N.O.; Avrova, N.F.; Kiselev, O.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 114(7): 42-44
1992
ISSN/ISBN: 0365-9615 PMID: 1421305 Document Number: 397119
The paper presents an experimental model of toxic influenza infection. The toxic form of influenza was shown to result in the activation of free radical processes accompanied by the accumulation of both lipid peroxidation products and methemoglobin and the decrease of alpha-tocopherol in erythrocytes, by the accumulation of NO. and nitrizyl complexes of heme iron in the blood. The activation of free radical processes was followed by the stimulation of antioxidant system in the blood. Thus, there was an increase of both superoxide dismutase activity in erythrocytes and ceruloplasmin content in the blood. The data obtained support the important role of the active products of free radical processes in the development of toxicosis under acute virus infections.