Experimental toxic pulmonary edema in white mice with influenza
Parusov, V.N.; Zhunko, V.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 83(2): 243-244
1977
ISSN/ISBN: 0365-9615 PMID: 851624 Document Number: 116254
Toxic pulmonary edema during influenza developed 3 hours after infection of mice with concentrated influenza viruses adapted to lung tissue. The toxic viral action is expressed in filling the alveoli with fluid exudate, by stasis in the pulmonary vessels, by eosinophilic necrosis of the epithelium in the bronchioles, and also by destruction of cells of the cortical layer of the thymus. The elaborated model aids in the understanding of malignant forms of influenza infection in man resulting in death.