The hypolipidemic action of water-soluble enterosorbents of cholesterol and bile acids in an experiment
Chistiakova, A.M.; Frolova, I.V.; Triufanov, V.F.; Vasil'eva, L.E.; Lozovskiĭ, V.T.; Ryzhenkov, V.E.
Eksperimental'naia i Klinicheskaia Farmakologiia 55(5): 41-44
1992
ISSN/ISBN: 0869-2092 PMID: 1305451 Document Number: 396132
Experiments on rats, guinea pigs and rabbits with experimental dyslipoproteinemia have revealed that the new water-soluble high-molecular weight polymers containing digitonin (ED) or a quaternary nitrogen atom (EA) have a more marked hypolipidemic action than cholestyramine and normalize lipoprotein metabolism. The digitonin-containing enterosorbent has been shown to decrease the absorption of 4-14C-cholesterol, while the nitrogen-containing enterosorbent diminishes the absorption of 3H-cholic acid.