Hypertrophy of the rat Golgi complex during enhancement of cholesterol and bile acids synthesis
Dubuisson, L.; Thines-Sempoux, D.; Bioulac-Sage, P.; Lapostolle, V.; Balabaud, C.
Journal of Submicroscopic Cytology 16(4): 721-726
1984
ISSN/ISBN: 0022-4782 PMID: 6502780 Document Number: 229049
There is some evidence that the Golgi apparatus could be involved in bile salts transport. In this study the morphology of the Golgi apparatus in rats with a chronic bile fistula or treated with 4% cholestyramine, a bile salts chelating agent was investigated. In both models liver histology was normal by light microscopy. With EM, compared to sham groups, the only obvious change was the enlargement of the Golgi complex. Morphometric data confirmed that the Golgi rich area volume density was almost doubled after chronic bile fistula or cholestyramine treatment. These data give another support for the participation of the Golgi complex in bile salts transport.