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Hepatic synthesis of bile acids. Biochemical steps and mechanisms of rate control

Mosbach, E.H.

Archives of Internal Medicine 130(4): 478-487

1972

ISSN/ISBN: 0003-9926
PMID: 4562147
Document Number: 52088
Bile acid synthesis in the liver is controlled by a negative feedback mechanism; hepatic bile acid synthesis varies inversely with the hepatic bile acid flux. Two regulatory enzymes appear to be involved in this process, cholesterol 7 alpha -hydroxylase and hydroxymethylglutarylcoenzyme A reductase. It seems likely that the activity of these enzymes varies in response to changes in the magnitude, circulation rate and composition of the bile acid pool.

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