Rabbit liver secretes oxidated lipoproteins in experimental atherosclerosis
Panasenko, O.M.; Sdvigova, A.G.; Sergienko, V.I.; Lopukhin, I.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 113(2): 143-144
1992
ISSN/ISBN: 0365-9615 PMID: 1611056 Document Number: 394124
It is shown in rabbits, that alimentary hypercholesterolemia proceeds with increasing lipid peroxidation in liver homogenate, blood serum and apo-B-containing lipoproteins. It is established in the model of liver perfusion in rabbits, that liver cells produce apo-B-containing level of lipid peroxidation. The lipid peroxidation increases in perfusate and in the fraction of lipoproteins (d less than 1,065 g/cm3) from this perfusate. Lipid peroxidation can interfere in the changing of physicochemical characteristics of lipoproteins at the stage of synthesis and secretion of lipoproteins by liver cells.