Blood lipoproteins in modeling of atherosclerosis and administration of protamine
Bozhko, G.K.; Voloshin, P.V.; Boĭko, T.P.; Kostiukovskaia, L.S.
Biulleten' Eksperimental'noi Biologii i Meditsiny 112(7): 44-46
1991
ISSN/ISBN: 0365-9615 PMID: 1793851 Document Number: 375717
The influence of protamine on the HDL, LDL, VLDL species concentration variation as well as on their cholesterol and protein content in respect to total blood serum cholesterol in different periods (1 and 7 months) of hypercholesteremia in rabbits is investigated. Daily administration of protamine (10 mg/kg) during 30 days to intact animals did not change the investigated parameters. In the early period of hypercholesteremia protamine considerably increased the content of all lipoprotein fractions. Under the conditions of prolonged hypercholesteremia the LDL and VLDL concentrations decreased by 23 and 60 per cent, respectively; HDL increased by 101 per cent.