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Evaluation of a high-performance thin-layer chromatographic technique for the determination of salbutamol serum levels in clinical trials

Le Roux, A.M.; Wium, C.A.; Joubert, J.R.; Van Jaarsveld, P.P.

Journal of Chromatography 581(2): 306-309

1992

ISSN/ISBN: 0021-9673
PMID: 1452625
Document Number: 394103
Salbutamol concentrations were determined by high-performance thin-layer chromatography in the sera of two sets of ten volunteers at hourly intervals for 6 h after taking one 8-mg slow-release tablet. The influence of time lapse in processing of serum samples, i.e. centrifugation, extraction and chromatography, was studied. A statistically significant instability of salbutamol in the sera of patients was found which was not present in standard drug-free serum samples spiked with salbutamol and used for construction of standard curves.

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