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Formation of a stable 99mTc-tri-hydrazidophosphine oxide (99mTc-THP) chelate

Corlija, M.; Katti, K.V.; Volkert, W.A.; Hoffman, T.J.; Higginbotham, C.; Holmes, R.A.

Journal of Nuclear Biology and Medicine 36(3): 296-300

1992

ISSN/ISBN: 0368-3249
PMID: 1486126
Document Number: 393084
Atri-hydrazidophosphine oxide (THP) ligand was synthesized and used to complex 99mTc in high yield (> 95%) by Sn(II) reduction of 99mTcO4-. 99mTc-THP has excellent stability in both 0.9% acqueous NaCl at neutral pH and in human serum at 37 degrees C. Biodistribution studies indicate minimal organ specificity and no significant in vivo release of 99mTcO4-. The ease of 99mTc complexation with THP and the high stability of 99mTc-THP suggests that this ligand may be used as a basis for the development of new imaging agents.

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