Formation of nitric oxide in animal tissues during inflammatory process
Kubrina, L.N.; Mordvintsev, P.I.; Vanin, A.F.
Biulleten' Eksperimental'noi Biologii i Meditsiny 107(1): 31-33
1989
ISSN/ISBN: 0365-9615 PMID: 2536568 Document Number: 329316
EPR evidence was obtained that more intensive formation of mononitrosyl non-heme iron complexes with diethyl-dithiocarbamate (DETC) took place in mouse liver when inflammation process was initiated in mice by the lipopolysaccharide isolated from Salmonella typhimurium bacterium wall DETC intraperitoneally injected bound with endogenous non-heme iron resulted with DETC-Fe complex formation. These complexes were as a traps of nitric oxide appeared in animal tissues, and NO-Fe-DETC complexes were observed. Phenazone known as a free radical process inhibitor lowered NO production in animal organism. The free radical processes were suggested to intensify under inflammation reactions and to cause the various amino groups oxidation to nitroso groups which were capable to release free nitric oxide.