Undetectable levels of tumor necrosis factor-alpha, nitric oxide and inadequate expression of inducible nitric oxide synthase in congenital hypothyroidism
Rodríguez-Arnao, M.D.; Rodríguez-Sánchez, A.; Rodríguez-Arnao, J.; Dulín- Iñiguez, E.; Cano, J.M.Bellón.; Muñoz-Fernández, M.A.
European Cytokine Network 14(1): 65-68
2003
ISSN/ISBN: 1148-5493 PMID: 12799216 Document Number: 553684
Objetive: To analyse the production of TNF-alpha and NO in euthyroid and hypothyroid newborns. Patients: A cross-sectional study was conducted involving 10 newborns diagnosed with primary congenital hypothyroidism (CH; group A) and 10 euthyroid children (group B). Results: There were undetectable plasma levels of TNF-alpha and NO in the hypothyroid children, however plasma levels of TNF-alpha (5.5+-0.5 pg/ml) and NO (5.6+-1.7 muM) were detected at normal levels in all euthyroid children. Moreover, expression of iNOS mRNA in PBMC, determined by RT-PCR, was negative in both groups of infants. Conclusion: TNF-alpha and NO production are both impaired in hypothyroid newborns. We report for the first time evidence of undetectable levels of TNF-alpha and NO in infants with CH.