Further studies on sister-chromatid exchange frequency in users of hormonal contraceptives
Murthy, P.B.; Prema, K.
Mutation Research 119(3): 351-354
1983
ISSN/ISBN: 0027-5107 PMID: 6402698 DOI: 10.1016/0165-7992(83)90184-7Document Number: 392881
Women using an estrogen-progestogen combination contraceptive exhibited an increased frequency of sister-chromatid exchange (SCE), supporting our previous observation. These elevated SCE frequencies tended to decline 3 months after the discontinuation of the pill. Women using a progestogen injectable contraceptive, on the other hand, had unaltered SCE rates. The analysis, in vitro; of mitomycin-C-induced SCE frequencies in women using either the combination or the progestogen injectable contraceptives showed significantly higher rates of induced SCE.