Effect of mouse age and genotype on the frequency of sister chromatid exchange in bone marrow cells
Lil'p, I.G.
Genetika 20(2): 260-265
1984
ISSN/ISBN: 0016-6758 PMID: 6423447 Document Number: 230730
No differences were found in both the baseline and mitomycin C induced levels of sister chromatid exchanges (SCE) between 101/H and C57BL/6J mice differing in chromosome mutability. An increase with the age of the spontaneous and mutagen induced SCE rates was similar in the strains compared, though instability of chromosomes was much higher in old 101/H than in C57BL/6J mice. Thus, no correlation was observed between chromosomal aberration and SCE levels in these strains. As 101/H mice were recently found to be DNA repair-deficient, possible connection of SCE and repair is discussed.