Sister-chromatid exchange and micronucleus induction as indicators of genetic damage in maternal and foetal cells
Henderson, L.; Cole, R.; Cole, J.; Cole, H.; Aghamohammadi, Z.; Regan, T.
Mutation Research 126(1): 47-52
1984
ISSN/ISBN: 0027-5107 PMID: 6422288 Document Number: 222505
The effectiveness of 3 compounds, procarbazine, mitomycin C and cyclophosphamide as inducers of sister-chromatid exchanges (SCE) in granulocyte-macrophage progenitor cells, in fetal liver and bone marrow from pregnant mice at day 17 of gestation were determined. Cyclophosphamide and procarbazine induced similar SCE frequencies in maternal and fetal cells. Mitomycin C was slightly less effective in fetal liver than in maternal bone marrow. In contrast to the results of SCE induction, cyclophosphamide produced more micronucleated polychromatic erythrocytes in fetal liver than in bone marrow. The SCE results for mitomycin C and procarbazine are compared with results obtained previously for micronuclei induction in 15 day pregnant animals.