Stress ulcer modulation by limbic system structures
Henke, P.G.; Ray, A.
Acta Physiologica Hungarica 80(1-4): 117-125
1992
ISSN/ISBN: 0231-424X PMID: 1345179 Document Number: 392586
A number of studies suggest that the telencephalic limbic system modulates stress ulcer development. The amygdala is assumed to connect sensory experiences, including stressful stimuli, with the emotional reactions and gastrointestinal effects these reactions normally produce. The hippocampal formation (entorhinal cortex, dentate gyrus, hippocampus) is part of a gating system, modulating the organism's coping ability. Changes in transmission in this temporal brain region are linked to individual differences in stress ulcer severity. Interactions among 'classical' transmitters and several neuropeptides mediate these differences.