Is there a limbic system equivalent of tardive dyskinesia?
Davis, K.L.; Rosenberg, G.S.
Biological Psychiatry 14(4): 699-703
1979
ISSN/ISBN: 0006-3223 PMID: 39641 Document Number: 144105
Long-term administration of antipsychotic drugs to animals induces super-sensitive mesolimbic postsynaptic dopamine receptors. It is possible that a similar process can occur in man. Following a reduction in the dose of antipsychotic medications, or their complete discontinuation, mesolimbic dopamine receptor supersensitivity could be reflected in rapid relapse of schizophrenic patients, the development of schizophrenic symptoms in patients with no prior history of schizophrenia, or in the necessity for ever-increasing doses of long-acting depot fluphenazine to maintain a remission.