Quantitation of chloroquine phosphate and primaquine phosphate in tablets using high performance liquid chromatography
Das Gupta, V.
Analytical Letters 19(13-14): 1523-1532
1986
ISSN/ISBN: 0003-2719 DOI: 10.1080/00032718608069123Document Number: 391673
Reverse phase high-performance liquid chromatography methods for the quantitation of chloroquine phosphate and primaquine phosphate in tablets have been developed. The methods require one column and 2 mobile phases for complete analysis of both drugs when present in combination. The methods are accurate and precise with percent relative standard deviations based on 6 injections of 0.5 and 0.9 for chloroquine and primaquine, respectively. The results of single ingredient, chloroquine phosphate tablets are in excellent agreement with the USP-NF method which is nonspecific. Primaquine interferes with the USP-NF method and not with the developed HPLC method. Both drugs appear to be very stable to heat.