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Use of thermo- and acid-stable proteinase inhibitor to suppress proteolytic activation in pulmonary inflammation

Kubyshkin, A.V.; Ogloblina, O.G.

Biulleten' Eksperimental'noi Biologii i Meditsiny 113(6): 580-582

1992

ISSN/ISBN: 0365-9615
PMID: 1446020
Document Number: 390065
A comparative study of thermo-acid stable proteinase inhibitor from rabbit serum and commercial drug contrykal was made on rats and in vitro experiments. Both inhibitors in equal doses effectively suppress proteolytic activity during initiation of lung inflammation. It was shown that the thermo-acid stable inhibitor possesses higher than contrykal, antielastase activity. A high effect of the acid stable inhibitors in the treatment of lung disease is suggested.

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