Top Abstract Purchase Related
Home
>
Node
>
Subnode

Property of a heat- and acid-stable inhibitor of serine proteinases from the blood serum to inhibit lymphcyte transformation stimulated by mitogens

Baranova, F.S.; Ogloblina, O.G.; Popova, L.K.; Platonova, L.V.; Berman, A.A.

Biulleten' Eksperimental'noi Biologii i Meditsiny 85(5): 569-572

1978

ISSN/ISBN: 0365-9615
PMID: 26437
Document Number: 133815
Thermo- and acid-stable serine proteases inhibitor from the rabbit blood serum (TASPI) was shown to inhibit the human peripheral blood lymphocytes transformation stimulated by phytohemagglutinin (PHA) or concanavalin A. The extent of inhibition depended on the concentration of the preparation and its specific activity. The maximal inhibition of lymphocytes proliferation constituted 50 to 70%. TASPI displayed no cytotoxic activity. Considerably more effective inhibition was demonstrated by TASPI addition to the culture medium 24 hours after the addition of PHA. The antiprotease activity of crude human serum and that inactivated under different conditions is described. The results obtained suggest the participation of TASPI in the control of biological activity of the lymphoid tissue cells.

Document emailed within 1 workday
Secure & encrypted payments

Ogloblina, O.G.; Platonova, L.V.; Paskhina, T.S. 1979: Inhibition of human granulocyte proteinases by a heat and acid-stable proteinase inhibitor from rabbit serum Biokhimiia 44(4): 672-683
Nartikova, V.F.; Paskhina, T.S. 1970: The kinetics of trypsin activity inhibition by a heat and acid-stable inhibitor in rabbit serum Biokhimiia 35(1): 187-195
Campbell, E.J.; Cury, J.D.; Shapiro, S.D.; Goldberg, G.I.; Welgus, H.G. 1991: Neutral proteinases of human mononuclear phagocytes. Cellular differentiation markedly alters cell phenotype for serine proteinases, metalloproteinases, and tissue inhibitor of metalloproteinases Journal of Immunology 146(4): 1286-1293
Walsmann, P.; Eppner, B.; Markwardt, F.; Stürzebecher, J.; Wagner, G. 1981: Synthetic inhibitors of serine proteinases. 27. the inhibitory effects of amides of 4-amidinophenylacetic acid and 4-amidinophenoxyacetic acid Die Pharmazie 36(6): 446-447
Gul'nik, S.V.; Feokharus, G.; Varchenko, N.V.; Lavrenova, G.I.; Stepanov, V.M. 1991: The effect of Legionella pneumophila metalloproteinase on certain human blood proteins. Cleavage of anti(1)-antitrypsin and acid-stable serine proteinase inhibitors Voprosy Meditsinskoi Khimii 37(3): 14-17
Chackalaparampil, I.; Bagrodia, S.; Shalloway, D. 1994: Tyrosine dephosphorylation of pp60c-src is stimulated by a serine/threonine phosphatase inhibitor Oncogene 9(7): 1947-1955
Ghosh, P. 1989: The role of serine proteinases and serine proteinase inhibitors in the pathobiology of connective tissues Nihon Seikeigeka Gakkai Zasshi 63(5): 643-652
Ferroni, R.; Menegatti, E.; Guarneri, M.; Taddeo, U.; Ascenzi, P.; Amiconi, G. 1988: Aromatic amidines: inhibitory effect on purified plasma serine proteinases, blood coagulation and platelet aggregation Il Farmaco; Edizione Scientifica 43(1): 5-13
Oreshkin, A.E.; Gudkova, M.V.; Miasishcheva, N.V. 1992: The expression of plasmalemma transcobalamin-Ii receptors on human blood lymphocytes stimulated by mitogens Biulleten' Eksperimental'noi Biologii i Meditsiny 114(8): 185-187
Oglobina, O.G.; Platonova, L.V.; Miasnikova, L.V.; Livshits, M.B.; Paskhina, T.S. 1980: Activity of granulocyte proteinases and level of acid-stable proteinase inhibitors in the bronchial secretions of children with bronchopathies of different etiology Voprosy Meditsinskoi Khimii 26(3): 387-392
Stoliarova, L.G.; Usakovskaia, T.S.; Tseĭtlin, P.I.; Pekhov, A.P. 1970: Effect of nitrous acid on the ability of DNA to inhibit transformation of Bacillus subtilis Biulleten' Eksperimental'noi Biologii i Meditsiny 69(3): 81-84
Holtorff, J.; Justus, B.; Meibbner, D.; Heinrich, H.J. 1973: Heat-stable alkaline phosphatase in maternal serum and the function of the placenta Zentralblatt für Gynakologie 95(31): 1057-1067
Ku, G.S.; Quigley, J.P.; Sultzer, B.M. 1983: The inhibition of the mitogenic stimulation of B lymphocytes by a serine protease inhibitor: commitment to proliferation correlates with an enhanced expression of a cell-associated arginine-specific serine enzyme Journal of Immunology 131(5): 2494-2499
Kay, J.; Heath, R.; Dahlmann, B.; Kuehn, L.; Stauber, W.T. 1985: Serine proteinases and protein breakdown in muscle Progress in Clinical and Biological Research 180: 195-205
Walsmann, P. 1977: Inhibition of serine proteinases by benzamidine derivatives Acta Biologica et Medica Germanica 36(11-12): 1931-1937
Lieser, H.; Tietze, K.W.; Rathgen, G.H. 1973: Studies on the significance of heat-stable alkaline phosphatase in the serum of pregnant woman to detect fetal distress Geburtshilfe und Frauenheilkunde 33(5): 395-400
Rudenko, V.G. 1986: Blood serum proteinases in the diagnosis of rheumatic diseases Vrachebnoe Delo 9: 7-9
Ogloblina, O.G.; Belova, L.A.; Malakhov, V.N. 1987: Effective method of isolating an acid-stable protease inhibitor from human urine Voprosy Meditsinskoi Khimii 33(4): 119-124
Seto, S.; Akahoshi, M.; Kusano, S.; Kitamura, S.; Hashiba, K. 1989: Central effect of aprotinin, a serine protease inhibitor, on blood pressure in spontaneously hypertensive and Wistar-Kyoto rats Advances in Experimental Medicine and Biology 247b: 49-54
Fradkin, V.A.; Lavrenchik, E.I.; Rozmainskaia, Z.N. 1971: Peripheral blood lymphocyte transformation, stimulated by phytagglutinins, in pulmonary tuberculosis Sovetskaia Meditsina 34(2): 15-19