Clinical and physiological effects of fluticasone propionate aqueous nasal spray in the treatment of perennial rhinitis
Scadding, G.K.; Lund, V.J.; Holmstrom, M.; Darby, Y.C.
RHINOLOGY. Suppl 11: 37-43
1991
ISSN/ISBN: 1013-0047 PMID: 1888556 Document Number: 3878
Although there are already topical corticosteroids which are safe and effective in intranasal use, the possibility for improvement exists and fluticasone propionate, with its low oral bioavailabilitv and possible increased potency when compared to beclomethasone dipropionate in the skin vasoconstrictor test, might be expected to prove superior to existing preparations. We found it effective and acceptable in 58% of our perennial rhinitis patients, 25% of whom had proved resistant to one or more of the available topical corticosteroids. Side effects were few and minor and there was no evidence of serious adverse effects on blood cells, renal or liver function or on glucose metabolism. Symptomatic improvement was roughly the same for all nasal symptoms, which was unexpected since usually topical corticosteroids are more effective against nasal blockage than against sneezing and rhinorrhoea. Eye symptoms, as expected, showed the least improvement. Only dexamethasone, which is systemically active when used topically, has proved to have much action against conjunctival inflammation.
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