Nasal remodeling in patient with perennial allergic rhinitis
Montero Mora, P.; Blanco, E.; Matta Campos, J.J.é; González Espinosa, A.; Guidos Fogelbach, G.; Tinajeros Castañeda, O.A.
Revista Alergia Mexico 50(3): 79-82
2003
ISSN/ISBN: 0002-5151 PMID: 12940105 Document Number: 554491
Remodeling is considered a new or different reconstruction of tissues. The airway remodeling is a consequence of changes induced by endothelial cells and extra-cellular matrix as a result of chronic inflammation. To show histological changes into mucosa in patients with perennial allergic rhinitis. We studied 26 patients with perennial allergic rhinitis, with evolution of 3 to 6 years, between 20 to 40 years old, without medical or immunological treatment. A turbinate biopsy was taken in all of them. We found enlargement of the basal membrane in 92.3%, subepithelial fibrosis in 92.4%, neutrophils in 100% of the cases, eosinophils in 100%, lymphocytes in 100%, edema in 46.2%, fragmented reticular fibers in 19.2%, and vascular dilatation in 11.1%. These results suggest nasal remodeling in patients with allergic rhinitis, although more structural studies about this pathology are necessary.