Measurement of antigen-specific IgE in nasal secretions of patients with perennial rhinitis

Small, P.; Barrett, D.; Frenkiel, S.; Rochon, L.; Cohen, C.; Black, M.; Small, P; Barrett, D; Frenkiel, S; Rochon, L; Cohen, C; Black, M

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Measurement of antigen-specific IgE in nasal secretions of patients with perennial rhinitis

Small, P.; Barrett, D.; Frenkiel, S.; Rochon, L.; Cohen, C.; Black, M.

Annals of Allergy 55(1): 68-71

1985

ISSN/ISBN: 0003-4738

PMID: 2409851

Document Number: 252670

Sixteen of 53 patients with rhinitis had positive skin tests corresponding with serum-specific IgE (RAST). Concomitant positive nasal secretion (NS) RAST was found in 10/16. Four patients with both negative skin tests and serum RAST had positive NS RAST. In a subset of patients with perennial rhinitis, specific IgE may be detected only in NS. Further studies are necessary to document the clinical relevance of such NS IgE antibodies.