Effect of chlorpromazine on the toxicity of doxorubicin in mice
Shibata, H.; Maekawa, I.; Furusawa, S.; Kawauchi, H.; Takayanagi, Y.; Sasaki, K.
Research Communications in Chemical Pathology and Pharmacology 71(3): 381-384
1991
ISSN/ISBN: 0034-5164 PMID: 2047578 Document Number: 383620
The effect of chlorpromazine (CPZ) on the toxicity of doxorubicin (DOX) were investigated in mice. CPZ significantly enhanced the acute toxicity and bone marrow toxicity induced by DOX. These results suggest the potentiation of DOX toxicity by CPZ is due to increase of sensitivity of mice to DOX.
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