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Effect of Hepatic P450 2e1 Activity Modulation on the Toxicity and Carcinogenicity of Diethylnitrosamine in Mice

Kaledin, V.I.; Ilnitskaya, S.I.; Vasyunina, E.A.; Popova, N.A.; Bogdanova, L.A.; Perepechaeva, M.L.; Grishanova, A.Y.

Biofizika 60(6): 1166-1173

2015

ISSN/ISBN: 0006-3029
PMID: 26841512
Document Number: 685750
In this paper, the biological effects of diethylnitrosamine have been studied under controlled conditions of its metabolism in mice of different ages. The data presented indicate that diethylnitrosamine in a non-metabolized form exerts general toxic and hepatocarcinogenic effects while alkylating agents of this compound produce toxic liver injury. To our knowledge, the data presented impel to revise the general notion of an exceptional role of mutagenic activation in the carcinogenic effect of chemicals.

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