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The multicatalytic proteinase (prosome, proteasome) : comparison of the eukaryotic and archaebacterial enzyme

Dahlmann, B.; Kopp, F.; Kuehn, L.; Hegerl, R.; Pfeifer, G.; Baumeister, W.

Biomedica Biochimica Acta 50(4-6): 465-469

1991

ISSN/ISBN: 0232-766X
PMID: 1801710
Document Number: 381297
Proteasomes isolated and purified from rat muscle tissue and from the archaebacterium Thermoplasma acidophilum have a very similar size and shape, but the subunit composition is less complex in the archaebacterium as compared to the eukaryotic particle. The archaebacterial enzyme contains a catalytic site with chymotryptic specificity, which is inhibited by serine proteinase inhibitors and clearly differs from the eukaryotic particle which has a minimum of three catalytic sites for peptide bond hydrolysis of a yet undefined mechanism.

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