Determination of enzyme activity in sarcoidosis--comparison of angiotensin convertase and collagen peptidase
Kirsten, D.; Lenich, R.; Müller, A.; Schaedel, H.
Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 39(16): 383-387
1984
ISSN/ISBN: 0044-2542 PMID: 6095547 Document Number: 233162
The diagnostic evidence of the ACE and CP activity alone is limited with regard to the specifity of sarcoidosis. In connection with the X-ray diagnostics and the histological ascertainment the determination of the two enzyme activities, however, is an enrichment of the programme of diagnostics. High ACE- and CP-values speak for the presence of numerous sarcoidosis granulomas and for the affection of many organs, respectively, when the sarcoidosis is ascertained. This fact is valuable in the diagnostics of sarcoidosis of the myocardium. For therapy controls or investigations of the course of the disease the two enzymes are to be used, since they give references to the activity of the disease. In this case the sensitivity of the ACE-determination seems to be larger than that one of the collagen peptidase.