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The 19 S multicatalytic "prosome" proteinase is a constitutive enzyme in Hela cells

Hendil, K.B.

Biochemistry International 17(3): 471-477

1988

ISSN/ISBN: 0158-5231
PMID: 2849441
Document Number: 312943
HeLa human carcinoma cells contain a high molecular mass (Mr approximately 700,000) proteinase that is identical with the ubiquitous eukaryotic 19 S cylindrical "prosome" particle. Prosomes constitute 0.6% of cell bulk protein as determined by immunochemical analysis. The prosome proteinase is not a heat shock protein, nor is it induced by cell crowding in culture or by serum deprivation. Pulse-chase experiments showed that the proteinase is relatively stable in the cells (t 1/2 approximately 5 days).

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Dahlmann, B.; Kopp, F.; Kuehn, L.; Hegerl, R.; Pfeifer, G.; Baumeister, W. 1991: The multicatalytic proteinase (prosome, proteasome): comparison of the eukaryotic and archaebacterial enzyme Biomedica Biochimica Acta 50(4-6): 465-469
Lin, L.; Sun, W.; Wang, L. 2015: Effects of mesenchymal stem cells on angiogenesis of cervical cancer Hela cancer cell line Hela in vivo Zhonghua Yi Xue Za Zhi 95(15): 1175-1178
Eugster, H.P.; Sengstag, C.; Meyer, U.A.; Hinnen, A.; Würgler, F.E. 1990: Constitutive and inducible expression of human cytochrome P450IA1 in yeast Saccharomyces cerevisiae: an alternative enzyme source for in vitro studies Biochemical and Biophysical Research Communications 172(2): 737-744
Ogura, H.; Yoshinouchi, M.; Kudo, T.; Imura, M.; Fujiwara, T.; Yabe, Y. 1993: Human papillomavirus type 18 DNA in so-called HEP-2, KB and FL cells--further evidence that these cells are Hela cell derivatives Cellular and Molecular Biology 39(5): 463-467
Steven, F.S.; Johnson, J.; Eason, P. 1993: A protein inhibitor, extracted from Hela cells, which recognises a cell surface protease on preneoplastic cells obtained from cervical smears Anticancer Research 13(4): 1059-1061
Inada, T.; Kasuga, T.; Nojiri, I.; Furuse, T.; Hiraoka, T. 1976: Linear energy transfer-dependent radiosensitivity of Burkitt lymphoma cells, with special references to human melanoma HMV, HeLa-S3, and L5178Y cells Gan 67(3): 399-402
Takeya, M.; Tokumitsu, S.; Kohnoe, K. 1980: Application of the enzyme histochemical method for the isolation of Hela variant inducibly producing the Kasahara isozyme of alkaline phosphatase Gan 71(5): 710-714
Svetlikova, S.B.; Abramova, M.V.; Kukushkin, A.N.; Darieva, Z.A.; Pospelova, T.V.; Pospelov, V.A. 2001: Constitutive activity of MAP kinase cascades in REF cells transformed by E1A and cHa-ras oncogenes Tsitologiia 43(10): 961-968
Dalaker, K.; Haug, E.; Prydz, H. 1985: Mouse trophoblast cells are constitutive producers of thromboplastin (factor III) in vitro Thrombosis and Haemostasis 54(2): 438-441
De Francesco, R.; Pessi, A.; Steinkühler, C. 1998: The hepatitis C virus NS3 proteinase: structure and function of a zinc-containing serine proteinase Antiviral Therapy 3(Suppl 3): 99-109
Silvestri, M.L.; Pivi, A.M.; Klein, C.; Pauly, P.C.; DaSilva, A.M. 1994: Constitutive overexpression of a GPI-anchored cell adhesion molecule in Dictyostelium discoideum cells Brazilian Journal of Medical and Biological Research 27(2): 427-430
De Lisle, R.C.; Bansal, R. 1996: Brefeldin A inhibits the constitutive-like secretion of a sulfated protein in pancreatic acinar cells European Journal of Cell Biology 71(1): 62-71
Saladino, C.; Ben-Hur, E. 1976: Heat-enhanced radioresponse in Hela cells Israel Journal of Medical Sciences 12(2): 134-138
Shin, T. 1980: Effects of halothane on the proliferation of Hela S3 cells MASUI. Japanese Journal of Anesthesiology 29(1): 11-20
Oster, W.; Lindemann, A.; Ganser, A.; Mertelsmann, R.; Herrmann, F. 1988: Constitutive expression of hematopoietic growth factor genes by acute myeloblastic leukemia cells Behring Institute Mitteilungen 83: 68-79
Roy, S.N.; Horwitz, S.B. 1984: Characterization of the association of radiolabeled bleomycin A2 with HeLa cells Cancer Research 44(4): 1541-1546
Bando, B.M.; Rosenbaum, M.J. 1973: Toxicity in Hela cells mediated by plastic wraps Laboratory Practice 22(1): 26 Passim
Porter, K.R.; Fonte, V.; Weiss, G. 1974: A scanning microscope study of the topography of Hela cells Cancer Research 34(6): 1385-1394
Sauk, J.J.; Van Kampen, C.L.; Norris, K.; Foster, R.; Somerman, M.J. 1990: Expression of constitutive and inducible HSP70 and HSP47 is enhanced in cells persistently spread on OPN1 or collagen Biochemical and Biophysical Research Communications 172(1): 135-142
Calcamuggi, G.; Lanzio, M.; Babini, G.; Martini, S.; Anfossi, G.; Emanuelli, G. 1990: Sodium taurocholate affects prostacyclin constitutive production by cultured human vascular endothelial cells Journal of Laboratory and Clinical Medicine 115(6): 756-760