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Effects of mesenchymal stem cells on angiogenesis of cervical cancer Hela cancer cell line Hela in vivo

Lin, L.; Sun, W.; Wang, L.

Zhonghua Yi Xue Za Zhi 95(15): 1175-1178

2015

ISSN/ISBN: 0376-2491
PMID: 26081364
Document Number: 679104
To explore the effects of bone marrow-derived mesenchymal stem cell (MSC) on angiogenesis of cervical cancer cell. MSCs from umbilical cord were mixed with cervical cancer cell line HeLa cells and subcutaneously plated in armpit area of nude mice to examine the in vivo tumor growth. Micro-vessel density (MVD) in tumor tissue was examined by CD34 immunohistochemical staining. Enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR) were employed to detect the expression of proangiogenesis factors. MSC could effectively promote the cervical cancer growth in vivo as compared with controls (P<0.05). The immunohistochemical results of CD34 staining showed that MVD of cervical cancer was higher in MSC group than that in control group (P<0.05). And there was a higher expression of vascular endothelial growth factor (VEGF) in MSC than controls. MSC promotes the in vivo angiogenesis of cervical cancer cell line by VEGF production.

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