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Efficacy of various antioxidants in experimental ischemia and myocardial infarct in the rat

Poliukhovich, G.S.; Vasil'eva, L.P.; Maslova, G.T.; Boboriko, T.L.; Speranskiĭ, S.D.

Voprosy Meditsinskoi Khimii 37(4): 54-56

1991

ISSN/ISBN: 0042-8809
PMID: 1750212
Document Number: 380396
Complex of vitamins E and C showed the most effective antinecrotic action in rats with simulated myocardial infarction in series of antioxidants studied: ascorbate, alpha-tocopherol, quercetine, derivatives of o-benzoquinone OBQ2 and OBQ3. Stabilization of lipid peroxidation in cardiomyocytes, increase in biomembranes stability and absence of distinct alterations in the antioxidative enzymatic system were found in rats with ischemia and myocardial infarction after treatment with the complex. Protective effect of the vitamins E and C complex was realised via antiradical mechanism.

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