The effect of adrenergic agents on the level of extracellular potassium normally and in myocardial ischemia (infarct)
Sysoliatina, N.A.
Farmakologiia i Toksikologiia 53(2): 75-80
1990
ISSN/ISBN: 0014-8318 PMID: 2164489 Document Number: 353943
Adrenergic drugs exert effects on the processes of potassium ions transmembrane distribution between the intra- and extracellular spaces. Drug-induced hypokalemia is the result of beta (predominantly beta-2) adrenergic stimulation. Arrhythmias in myocardial ischemia occur at the combination of hypercatecholaminemia and rapid transmembrane distribution of potassium ions between the intra- and extracellular spaces. The distribution results in the association of the increased local extracellular potassium concentration in the myocardium and rapidly developing hypokalemia.