Beta-adrenergic reactivity in patients with myocardial infarct according to the antihemolytic test
Sominskiĭ, V.N.; Anshelevich, I.V.; Okun', K.V.
Kardiologiia 30(5): 24-28
1990
ISSN/ISBN: 0022-9040 PMID: 1975281 Document Number: 349647
Propranolol antihemolytic test parameters calculated with the Hill mathematical model from dose-dependent curves of saturation were studied in 27 patients with myocardial infarction. Erythrocyte beta-adrenoreceptors showed higher sensitivity to propranolol in patients with myocardial infarction within 3 days of the disease. Three weeks after therapy, changes were found in the erythrocyte membranes solely in patients receiving beta-adrenoblockers. The changes are indicative of lower sensitivity of beta-adrenoreceptors to the beta-blocker. Persons with varying responses to propranolol were detected among the patients with myocardial infarction, which may be used to define indications for beta-adrenoblocker therapy.