Effect of the long-term exposure of the isolated myometrium from nonpregnant rats to serum from pregnant women on its contractile activity and the beta-adrenergic reactivity
Sazanov, A.V.; Tsirkin, V.I.; Dvorianskiĭ, S.A.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 86(1): 103-112
2000
ISSN/ISBN: 0869-8139 PMID: 10740843 Document Number: 523288
Pregnant women's blood serum (the whole as well as 50- and 100-diluted) did not alter parameters of spontaneous motility, i.e. it did not affect the uterus myocytes' spontaneous motility, whereas the whole or 50-diluted serum raised considerable the rat myometrium's beta-adrenoreaction. The data obtained suggest that the beta-adrenoreaction of the rat uterus' myocytes increases after a prolonged contact with pregnant women's blood serum which may be due to the beta-adrenoreceptor synthesis activation and to an increase in their concentration because of diffusion from the blood serum. This suggests existence of humoral mechanisms of the myometrium beta-adrenoreaction regulation, the mechanisms creating the optimum uterus' contractile activity.