Gas chromatography and mass spectrometry of dimethylethylsilyl ether derivatives of norethisterone metabolites in plasma
Rizk, M.S.; Zakhari, N.A.; Walash, M.I.; Toubar, S.S.; Brooks, C.J.; Anderson, R.
Acta Pharmaceutica Nordica 3(4): 205-210
1991
ISSN/ISBN: 1100-1801 PMID: 1781912 Document Number: 379189
Metabolites isolated from human plasma after oral administration of norethisterone were assayed as their novel dimethylethylsilyl ether derivatives by gas chromatography-mass spectrometry-ion selective monitoring. The major metabolite is 3.alpha., 5.alpha.-tetrahydronorethisterone. The unchanged drug is present in a measurable amount even after 8 h of drug administration. The method is accurate, precise and highly sensitive.
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