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Pharmacokinetics of tryptamide following intravenous administration in rats

Szumiło, H.; Lutnicki, K.

Polish Journal of Pharmacology and Pharmacy 43(1): 21-25

1991

ISSN/ISBN: 0301-0244
PMID: 1837608
Document Number: 376288
Plasma and tissue levels of N-3-pyridoyl-tryptamine (tryptamide) vs. time were determined in rats following iv administration of various doses: 6.25, 12.5, 25.0 and 37.5 mg/kg. The course of changes was described by the two-compartment open model. The distribution rate constant (.alpha., min-1), the elimination rate constant (.beta., min-1), the body clearance (Cltot, ml/min) and its fraction absorbed (f, %) values changed depending on the dose and were respectively: 0.107-0.266, 0.0068-0.0126, 5.39-11.59 and 31.77-66.70.

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