Pharmacokinetics of buflomedil after intravenous and oral administration
Rey, E.; Barrier, G.; d'Athis, P.; de Lauture, D.; Richard, M.O.; Lirzin, J.P.; Sureau, C.; Olive, G.
International Journal of Clinical Pharmacology Therapy and Toxicology 18(10): 437-441
1980
ISSN/ISBN: 0174-4879 PMID: 7203720 Document Number: 164481
Pharmacokinetics studies were conducted in 4 patients who received buflomedil 100 mg intravenously and in 3 volunteers who received buflomedil 450 mg per os. Buflomedil concentrations were determined by a gas liquid chromatography method. Buflomedil levels declined multiphasically with a mean clearance after intravenous administration of -0,034 (1 h-1 kg-1). The decline appeared to be monophasic after oral administration. In both cases the overall half-life is short, mean 2.07 hrs (range, 1,47-2,6 hrs).