Pharmacokinetics of pheniramine (Avil) and metabolites in healthy subjects after oral and intravenous administration
Witte, P.U.; Irmisch, R.; Hajdú, P.
International Journal of Clinical Pharmacology Therapy and Toxicology 23(1): 59-62
1985
ISSN/ISBN: 0174-4879 PMID: 3988394 Document Number: 496
The pharmacokinetics of pheniramine values up to 72 h were 3035-4662 (i.v.) and 3507-5768 (ng/ml .times. h) (oral). The terminal half-lives were estimated to range between 8 and 17 h (i.v.) and 16 and 19 h (oral). Serum levels of the N-desmethyl derivative remained very low (up to 21 ng/ml), but were still detectable after 72 h. Serum levels of the N-didesmethyl derivative were below the detection limit. The amount of pheniramine excreted in the urine for up to 120 h varied between 5.7 and 11.6 mg and 10.2 and 13.2 mg after i.v. and oral administration, respectively. Unlike the serum, considerable fractions of the drug occurred as metabolites in urine. Values were 8.1-16.4 mg (i.v.) and 7.4-13.3 mg (oral) for N-desmethyl pheniramine, 0.4-2.9 mg (i.v.) and 0.2-0.8 mg (oral) for N-didesmethyl pheniramine.
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