Pharmacokinetics of dimetindene after intravenous and oral administration to healthy volunteers
Arnera, V.; Wermeille, M.; Wellman, M.; Llull, J.B.; Althaus, M.A.; Balant, L.P.
Arzneimittel-Forschung 40(12): 1346-1348
1990
ISSN/ISBN: 0004-4172 PMID: 2095130 Document Number: 714
The pharmacokinetics of dimetindene (dimethindene maleate, Fenistil, CAS 3614-69-5) were studied after its intravenous and oral administration to 8 healthy male volunteers. Serum concentrations were measured for 48 h using an enzyme-linked immunosorbent assay. Pharmacokinetic parameters (AUC, t1/2, CLs, Vd and F) were calculated using the clearance approach.
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