Physiological model of sulbactam pharmacokinetics in rats and humans. Distribution of sulbactam in the tissues after intravenous and intramuscular administration
Manuĭlov, K.K.
Antibiotiki i Khimioterapiia 36(2): 31-34
1991
ISSN/ISBN: 0235-2990 PMID: 2025116 Document Number: 386185
A 10-compartment physiological model of sulbactam pharmacokinetics is described. The model provides simulation of the pharmacokinetic profiles of the drug observed after its intra-muscular and intravenous administration in rats and humans. The adequate description of the drug distribution in human blood suggested that the model was applicable in designing rational schemes of sulbactam use.
Document emailed within 1 workday
Related Documents
Arden, W.A.; Barker, D.E.; Strodel, W.E.; Record, K.; Leader, G.; Derbin, M.; Gellin, G.; Schwartz, R.W. 1994: Effect of cardiogenic shock on pharmacokinetics and tissue distribution of ampicillin-sulbactam Circulatory Shock 44(3): 138-147Koga, H.; Tomono, K.; Hirakata, Y.; Kohno, S.; Abe, K.; Kawamoto, S.; Kusano, S.; Tanaka, K.; Morikawa, N.; Sugiyama, H.; Katsumata, T.; Sasayama, K.; Shimoguchi, K.; Hashimoto, A.; Matsumoto, Y.; Inoue, Y.; Ishiguro, M.; Hori, H.; Mashimoto, H.; Dotsu, Y.; Tanaka, H.; Imamura, Y.; Kanda, T.; Hara, K. 1996: Clinical evaluation of sulbactam/cefoperazone for lower respiratory tract infections. Correlation between the efficacy of sulbactam/cefoperazone and beta-lactamase Japanese Journal of Antibiotics 49(8): 800-807
Kouda, M.; Kumagai, I.; Kobayashi, J.; Sugai, R.; Matsuzaki, H. 1991: Combined effect of sulbactam/cefoperazone and other antibiotics against clinical isolates of multi-resistant strains. II. In vitro combined effects of sulbactam/cefoperazone with imipenem/cilastatin, cefuzonam, flomoxef, amikacin or tobramycin Japanese Journal of Antibiotics 44(2): 130-139
Dalhoff, A.; Koeppe, P.; von Kobyletzki, D. 1981: Studies on the pharmacokinetics of amoxicillin after intravenous, intramuscular and oral administration Arzneimittel-Forschung 31(7): 1148-1157
Ahr, H.J.; Krause, H.P.; Suwelack, D.; Weber, H. 1988: Pharmacokinetics of nisoldipine. II. Distribution to and elimination from tissues and organs following single or repeated administration of [14C]nisoldipine to rats and dogs Arzneimittel-Forschung 38(8): 1099-1104
Krause, H.P.; Ahr, H.J.; Siefert, H.M.; Steinke, W.; Suwelack, D. 1988: The pharmacokinetics of nitrendipine. II. Distribution to and elimination from organs and tissues of rats and dogs after single or repeated administration of [14C]nitrendipine Arzneimittel-Forschung 38(11): 1599-1604
Warnke, J.P.; Wildfeuer, A.; Eibel, G.; Pfaff, G.; Klammer, A. 1998: Pharmacokinetics of ampicillin/sulbactam in patients undergoing spinal microneurosurgical procedures International Journal of Clinical Pharmacology and Therapeutics 36(5): 253-257
Siefert, H.M.; Maruhn, D.; Scholl, H. 1986: Pharmacokinetics of ciprofloxacin. 2nd communication: distribution to and elimination from tissues and organs following single or repeated administration of [14C]ciprofloxacin in albino rats Arzneimittel-Forschung 36(10): 1503-1510
Blardi, P.; Messa, G.L.; Urso, R.; Di Perri, T. 1993: Pharmacokinetics and pharmacodynamics of dermatan sulfate after intravenous and intramuscular administration to healthy volunteers International Journal of Clinical Pharmacology Research 13(4): 231-238
Blackwell, B.G.; Leggett, J.E.; Johnson, C.A.; Zimmerman, S.W.; Craig, W.A. 1990: Ampicillin and sulbactam pharmacokinetics and pharmacodynamics in continuous ambulatory peritoneal dialysis (CAPD) Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 10(3): 221-226
Porchet, H.C.; Le Cotonnec, J.Y.; Canali, S.; Zanolo, G. 1993: Pharmacokinetics of recombinant human follicle stimulating hormone after intravenous, intramuscular, and subcutaneous administration in monkeys, and comparison with intravenous administration of urinary follicle stimulating hormone Drug Metabolism and Disposition: the Biological Fate of Chemicals 21(1): 144-150
Stromberg, B.V.; Reines, H.D.; Hunt, P. 1986: Comparative clinical study of Sulbactam and ampicillin and clindamycin and tobramycin in infections of soft tissues Surgery Gynecology and Obstetrics 162(6): 575-578
Hardin, T.C.; Butler, S.C.; Ross, S.; Wakeford, J.H.; Jorgensen, J.H. 1994: Comparison of ampicillin-sulbactam and ticarcillin-clavulanic acid in patients with chronic renal failure: effects of differential pharmacokinetics on serum bactericidal activity PharmacoTherapy 14(2): 147-152
Lu, L.I.; Wang, X.; Wang, L.; Zhang, B.; Yan, S.; Zhao, X.; Li, W.; Cui, M.; Gao, M.; Zhang, Y.; Wu, Y. 2011: Pharmacokinetics of rh-IFNalpha-2a-NGR, a tumor targeted-therapy candidate, following intramuscular administration to mice, rats and monkeys Die Pharmazie 66(9): 690-693
Kurimoto, T.; Kobayashi, H.; Inoue, A.; Deguchi, T.; Okachi, R. 1983: Pharmacokinetic studies on micronomicin in rats. Comparison of intramuscular and drip intravenous administration models Japanese Journal of Antibiotics 36(11): 3254-3261
Szumiło, H.; Lutnicki, K. 1991: Pharmacokinetics of tryptamide following intravenous administration in rats Polish Journal of Pharmacology and Pharmacy 43(1): 21-25
Yang, F-Ying.; Zhang, W-Ping.; Wang, X-Yu.; Yang, W-Cheng.; Dang, H-Wan. 2014: Pharmacokinetics of SN-38 in rats and tissue distribution of 7-ethyl-10-hydroxycamptothecin in mice after intravenous injection of irinotecan hydrochloride nanoparticles Yao Xue Xue Bao 49(7): 1029-1033
Mays, D.C.; Dixon, K.F.; Balboa, A.; Pawluk, L.J.; Bauer, M.R.; Nawoot, S.; Gerber, N. 1991: A nonprimate animal model applicable to zidovudine pharmacokinetics in humans: inhibition of glucuronidation and renal excretion of zidovudine by probenecid in rats Journal of Pharmacology and Experimental Therapeutics 259(3): 1261-1270
Anderson, K.L.; Neff-Davis, C.A.; Davis, L.E.; Bass, V.D. 1990: Pharmacokinetics of flunixin meglumine in lactating cattle after single and multiple intramuscular and intravenous administrations American Journal of Veterinary Research 51(9): 1464-1467
Germiniani, R.; Casiraghi, S.; Pace, M.; Caspani, P.; Trabucchi, E. 1992: Sulbactam-ampicillin in surgery. our experience Minerva Chirurgica 47(20): 1627-1629