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Relationship between topological properties and biological activity of platinum (II) complexes

Romanowska, K.; Kuduk-Jaworska, J.

Archivum Immunologiae et Therapiae Experimentalis 39(1-2): 75-84

1991

ISSN/ISBN: 0004-069X
PMID: 1804055
Document Number: 375515
A graph-theoretical method is applied to model of the relations between structure and biological activity of the anticancer Pt(II) complexes. Values of LD50, ID90, TI and % of ILS resulted from the treatment of animals bearing experimentalis ADJ/PC6 or L1210 tumors, available in the literature, were used as parameters characterizing the antitumor activity of platinum complexes. These results indicate that it is possible to find a topological description of these complexes which could be useful in their structure - activity investigations.

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