Top Abstract Purchase Related
Home
>
Node
>
Subnode

Antitumor activity of water-soluble platinum (II) complexes of 1,2-cyclohexanediamine isomers

Kidani, Y.; Noji, M.; Tsukagoshi, S.; Tashiro, T.

Gan 69(2): 263-265

1978

ISSN/ISBN: 0016-450X
PMID: 680465
Document Number: 128308
Dichloroplatinum(II) complexes of 1,2-cyclohexanediamine isomers were reported to have high antitumor activity against leukemia L-1210 and P-388, but they were hardly soluble in water and, therefore, dibromo- and diiodo-platinum(II) complexes of 1,2-cyclohexanediamine isomers were prepared. They were not soluble in water but showed high antitumor activity. When the chloride ions are replaced with sulfate ions, they become soluble and also they are anti-tumor active. Bismonobromoacetatoplatinum (II) complexes were synthesized and tested. Mono- and bis-(D-glucuronato)platinum(II) complexes of 1,2-cyclohexanediamine isomers were newly synthesized. All of them were freely soluble in water and showed high antitumor activity with low toxicity. The chelated mono(D-glucuronato)platinum(II) was found to be more effective than the monodentate bis(D-glucuronato)platinum (II) complexes.

Document emailed within 1 workday
Secure & encrypted payments

Hacker, M.P.; Khokhar, A.R.; Krakoff, I.H.; Brown, D.B.; McCormack, J.J. 1986: Water-soluble N-substituted iminodiacetato(1,2-diaminocyclohexane)-platinum(II) complexes as potential antitumor agents Cancer Research 46(12 Part 1): 6250-6254
Saegusa, Y.; Eriguchi, M.; Kidani, Y.; Matsuzawa, A.; Takeda, Y. 2001: Antitumor effects of a new lipophilic platinum compound, trans-bis(n-valerato)(1R,2R-cyclohexanediamine)(oxalato)platinum(IV), in mice Anticancer Research 21(1a): 245-252
Schwartz, P.; Meischen, S.J.; Gale, G.R.; Atkins, L.M.; Smith, A.B.; Walker, E.M. 1977: Preparation and antitumor evaluation of water-soluble derivatives of dichloro(1,2-diaminocyclohexane)platinum(II) Cancer Treatment Reports 61(8): 1519-1525
Rosenberg, B. 1975: Possible mechanisms for the antitumor activity of platinum coordination complexes Cancer ChemoTherapy Reports 59(3): 589-598
Endo, K.; Akamatsu, K.; Matsumoto, T.; Morikawa, K.; Koizumi, M.; Mitsui, H.; Koizumi, K. 1992: Antitumor effects of three platinum complexes, (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)-platinum (II) monohydrate (DWA2114R), cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) (CBDCA) and cis-diamminedichloroplatinum(II) (CDDP), in mice Anticancer Research 12(1): 49-58
Mailliet, P.; Segal-Bendirdjian, E.; Kozelka, J.; Barreau, M.; Baudoin, B.; Bissery, M.C.; Gontier, S.; Laoui, A.; Lavelle, F.; Le Pecq, J.B. 1995: Asymmetrically substituted ethylenediamine platinum(II) complexes as antitumor agents: synthesis and structure-activity relationships Anti-Cancer Drug Design 10(1): 51-73
Zhang, Y.; Tang, H.-m.; Li, A.; Xu, L.-f.; Chen, J.-n.; Huang, S.; He, L. 2015: Determination of six C-Glycoside flavones and antitumor activity of water-soluble total flavonoids from Isodon lophanthoides var. gerardianus Zhongguo Zhong Yao Za Zhi 40(8): 1543-1547
Romanowska, K.; Kuduk-Jaworska, J. 1991: Relationship between topological properties and biological activity of platinum (II) complexes Archivum Immunologiae et Therapiae Experimentalis 39(1-2): 75-84
Krasnopolskaya, L.M.; Shuktueva, M.I.; Avtonomova, A.V.; Yarina, M.S.; Dzhavakhyan, B.R.; Isakova, E.B.; Bukhman, V.M. 2016: Antitumor and Antioxidant Properties of Water-Soluble Polysaccharides from Submerged Mycelium of Flammulina velutipes Antibiotiki i Khimioterapiia 61(11-12): 16-20
Kelland, L.R.; Abel, G.; McKeage, M.J.; Jones, M.; Goddard, P.M.; Valenti, M.; Murrer, B.A.; Harrap, K.R. 1993: Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): an orally active platinum drug Cancer Research 53(11): 2581-2586
Sawada, M.; Ozaki, M.; Hongo, J.; Hirota, Y.; Inagaki, M.; Taniguchi, H.; Tateishi, R.; Mori, Y. 1987: Antitumor activity of platinum analogs against human ovarian tumors heterotransplanted into nude mice Gan to Kagaku Ryoho. Cancer and ChemoTherapy 14(3 Part 1): 693-698
Siddik, Z.H.; Thai, G.; Yoshida, M.; Zhang, Y.P.; Khokhar, A.R. 1994: Tetravalent platinum complexes with ammine/amine carrier ligand configuration: circumvention of platinum resistance in vivo Anti-Cancer Drug Design 9(6): 495-509
Das, C.; Langone, J.J. 1987: Correlation between antitumor activity of protein a and in vivo formation of defined high molecular weight complexes with immunoglobulin G in BALB/c mice Cancer Research 47(8): 2002-2007
Brassinne, C.; Atassi, G.; Frühling, J.; Penasse, W.; Coune, A.; Hildebrand, J.; Ruysschaert, J.M.; Laduron, C. 1983: Antitumor activity of a water-insoluble compound entrapped in liposomes on L1210 leukemia in mice Journal of the National Cancer Institute 70(6): 1081-1086
Kamata, K.; Okubo, M.; Marumo, F. 1979: Water soluble vitamins in patients with chronic renal failure and effect of B6 administration of immunological activity Proceedings of the Clinical Dialysis and Transplant Forum 9: 194-196
Kamata, K.; Okubo, M.; Marumo, F.; Nango, H.; Higashishiba, H.; Kanayama, K.; Koyama, R. 1981: Water soluble vitamins in patients with chronic renal failure and effect of B6 administration on immunological activity Nihon Jinzo Gakkai Shi 23(2): 145-151
Chen, J.; Wanming, D.; Zhang, D.; Liu, Q.; Kang, J. 2005: Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells Die Pharmazie 60(1): 57-61
Heber, B.; Horsch, W. 1982: On the different release kinetics of water-soluble and lipid-soluble forms of hydroxyquinoline in oleogel ointment bases Die Pharmazie 37(3): 192-194
Wong, E.; Giandomenico, C.M. 1999: Current status of platinum-based antitumor drugs Chemical Reviews 99(9): 2451-2466
Kuduk-Jaworska, J. 1984: Platinum complexes as potential antineoplastic drugs Postepy Higieny i Medycyny Doswiadczalnej 38(3): 281-322