Effects of high-dose fentanyl on intraductal pressure in the choledochoduodenal junction in dogs
Miyamoto, M.; Iwasaki, H.; Omote, T.; Namiki, A.
Masui. Japanese Journal of Anesthesiology 40(11): 1682-1685
1991
ISSN/ISBN: 0021-4892 PMID: 1766120 Document Number: 372330
Changes in intraductal pressure in choledochoduodenal junction were studied following intravenous administration of fentanyl in dogs. The intraductal pressure was measured with constant-rate infusion method. A statistically significant increase in the intraductal pressure was demonstrated after the intravenous administration of fentanyl 5 micrograms.kg-1 and 75 micrograms.kg-1. The increase in intraductal pressure following fentanyl administration at a dose of 75 micrograms.kg-1 persisted for more than 5 hours. We conclude that in case of intravenous high-dose fentanyl administration special attention should be paid to spasm of choledochoduodenal sphincter.