Combined effects of fentanyl and diazepam on hemodynamics and myocardial blood flow in dogs with normal and ischemic heart
Furuya, Y.; Nomura, M.; Nomura, Y.; Yokoyama, S.; Shirai, K.; Fujita, M.
Masui. Japanese Journal of Anesthesiology 36(3): 370-376
1987
ISSN/ISBN: 0021-4892 PMID: 3613053 Document Number: 289904
In dogs with normal and ischemic heart, fentanyl (30 .mu.g/kg) or diazepam (0.3 mg/kg) alone and their combination (same doses) were administered intravenously to compare their effects on hemodynamics and myocardial blood flow. Thirty adult mongrel dogs were divided into three groups. Combination of fentanyl and diazepam showed a slight effects on hemodynamics, and produced less decrease of cardiac output and left ventricular contractility in ischemic heart. Also, the combination showed a slight effects on myocardial blood flow, and produced a greater increase in the flow of ischemic area in ischemic heart. The results indicate that combination of fentanyl and diazepam compensates for the disadvantage of fentanyl or diazepam alone by controlling the interaction between myocardial depression of fentanyl and vasodilatation of diazepam. We conclude that the combination method appears to be useful for induction of cardiac anesthesia, particularly in ischemic heart disease.