Effects of isosorbide dinitrate on systemic haemodynamics, regional coronary blood flow and ST-segment. a study on normal and/or ischaemic dog heart
Berdeaux, A.; Giudicelli, J.F.
La Nouvelle Presse Medicale 11(27): 2043-2047
1982
ISSN/ISBN: 0301-1518 PMID: 7110963 Document Number: 182984
In dogs, isosorbide dinitrate (ISDN) reduced venous return, and in spite of mild tachycardia the cardiac output fell by reduction of stroke volume. Depending on modalities of administration, the drug had little or no influence on systemic arterial pressure. Cardiac inotropism remained unchanged. Heart work was consistently reduced. During temporary occlusion of the left coronary artery, ISDN had little effect on regional blood flow in normal myocardial areas but increased transmural blood flow and the endocardium/epicardium perfusion ratio in ischaemic areas. The redistribution of coronary blood flow produced by ISDN to the benefit of ischaemic areas was accompanied by a simultaneous decrease in the intensity of electric ischaemia.