Hemodynamic effects of high dose fentanyl anesthesia during induction, intubation and surgical stimulations in normal subjects
Ochiai, R.; Masuda, J.; Takeda, J.; Nagano, M.
Masui. Japanese Journal of Anesthesiology 31(4): 350-355
1982
ISSN/ISBN: 0021-4892 PMID: 7109226 Document Number: 184577
High dose fentanyl anesthesia (50-100 .mu.g/kg) is reported to be a safe technique for open heart surgery because of its minimal cardiovascular effects, but its use for patients without cardiovascular involvements has not been described. Hemodynamic studies were performed on noncardiac surgical patients by using 20 .mu.g/kg of fentanyl for induction of anesthesia and 40 .mu.g/kg for maintenance. During induction, slight decrease of cardiac output and increase of cardiac preload and after load were found, but there was minimal change during intubation and surgical stimulations. Total body O2 consumption decreased largely, but myocardial O2 consumption changed little as manifested in rate-pressure product. Evidently, high dose fentanyl provides slight cardiovascular depression on normal subjects and is safe to be administered with minimal cardiovascular side effects.