The receptor binding of corticosterone in the monoaminergic structures of the rat brain after a neonatal block of the hypophysis-adrenal system
Garina, I.A.; Rakitskaia, V.V.; Shaliapina, V.G.
Problemy Endokrinologii 36(5): 65-68
1990
ISSN/ISBN: 0375-9660 PMID: 2080146 Document Number: 363287
Specific binding of 3H-corticosterone in different cerebral structures of 1- and 2-month-old rats was studied after neonatal blockade of the hypophyseal-adrenal system caused by hydrocortisone administration (0.1 mg per animal during the first 5 days of the life of rats). Neonatal administration of the hormone caused a decrease in receptor binding of 3H-corticosterone in the hypothalamus, pituitary body, striatum, black substance and blue spot in 1-month-old animals. In 2-month-old animals specific binding of the hormone in all the investigated structures was restored up to the control level. Regeneration of hormonal function was noted in the same period. The results indicate the involvement of the central monoaminergic structures in the regulation of the hypophyseal-adrenal system after the feedback-type mechanism.