Comparative studies of 35S-hemineurine and 35S-thiamine distribution and binding by proteins in the neural structures of the rat brain
Filippova, L.B.; Rozanov, A.I.
Voprosy Meditsinskoi Khimii 26(5): 643-646
1980
ISSN/ISBN: 0042-8809 PMID: 7423880 Document Number: 159601
35S-Hemineurine penetrated across the blood-brain barrier more rapidly than 35S-thiamin within the first 30 min after intravenous administration. Within 24 hrs content of 35S-thiamin in the neurones exceeded by 34% its concentration in glia and by 200% -- in myelin fraction. 35S-Hemineurine was bound slightly with brain proteins as compared with thiamin and it was removed at the higher rate from brain regions and subcellular structures.
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