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The secretion of alpha-melanotropin in diseases of the hypothalamus-hypophysis-adrenal cortex system

Slavnov, V.N.; Luchitskiĭ, E.V.; Oleĭnik, V.A.; Komissarenko, I.B.

Problemy Endokrinologii 36(2): 40-43

1990

ISSN/ISBN: 0375-9660
PMID: 2163527
Document Number: 364408
The paper is concerned with the results of investigation of the blood concentration of alpha-melanocyte-stimulating hormone (alpha-MSH), hypophyseal reactivity to stress caused by insulin hypoglycemia in 26 patients with diseases of the hypothalamo-hypophyseal-adrenocortical system (Itsenko-Cushing disease and syndrome, hypothalamic syndrome of the pubertal period). A radioimmunoassay was used for the determination of the blood levels of alpha-MSH, ACTH and cortisol. In healthy persons the blood level of alpha-MSH rose 2-fold as compared to the basal one under the influence of insulin hypoglycemia-induced stress. In patients with Itsenko-Cushing disease at the active stage, alpha-MSH blood concentration was significantly elevated and a hypophyseal reaction to stress was disturbed. In Itsenko-Cushing syndrome, a decrease in the blood basal level of alpha-MSH and a hormone reaction to insulin hypoglycemia was noted. In patients with the hypothalamic syndrome of the pubertal period the blood level of alpha-MSH was raised and hypophyseal reactivity to insulin hypoglycemia was changed. Correlation analysis of the levels of alpha-MSH, ACTH and cortisol showed direct noticeable close relationships between the level of alpha-MSH and ACTH concentration in healthy persons and direct high close relationships between these indices in patients with Itsenko-Cushing disease. Correlation between the blood levels of alpha-MSH and cortisol was undetectable.

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Breuer, H. 1975: Normal values and samples of findings in diseases of the hypophysis and the adrenal cortex Medizinische Klinik 70(23): 1005-1006
Kudriashov, B.A.; Shapiro, F.B.; Ul'ianov, A.M. 1977: Participation of the hypophysis-adrenal cortex system in the realization of thrombin clearance in immobilization stress Problemy Endokrinologii 23(6): 43-48
Zefirova, G.S.; Ibragimova, G.V.; Beĭsugurov, M.S.; Shmushkovich, B.I. 1986: Status of the hypophysis-adrenal cortex system during treatment with glucocorticoids by the method of intermittent (every other day) administration Terapevticheskii Arkhiv 58(10): 114-117
Razina, L.G.; Katsiia, G.V. 1974: Functional activity of the hypothalamus-pituitary gland-adrenal cortex system in dogs after prolonged administration of dexamethasone Problemy Endokrinologii 20(2): 101-105
Von der Nahmer, D.; Siedek, M. 1972: Hypothalamus-anterior pituitary-adrenal cortex system and glucose metabolism under continuous, circadian and alternating steroid treatment in kidney transplantation Die Medizinische Welt 23(41): 1413-1414
Freudiger, U. 1986: A literature review of adrenal cortex diseases in the cat and a description of a case of primary adrenal cortex insufficiency Schweizer Archiv für Tierheilkunde 128(5): 221-230
Revskoĭ, I.K.; Zaĭchuk, A.S.; Solov'ev, A.V. 1984: Effect of hyperstimulation of the vestibular analyzer on the adrenocorticotropic function of the hypophysis and adrenal cortex Vestnik Otorinolaringologii 1: 29-32
Vrbová, H.; Gregorová, I. 1972: The diurnal rhythm of 11-hydroxycorticoids in plasma in endocrinopathies with hypophysis and adrenal cortex disorders and in control persons Sbornik Lekarsky 74(9): 263-275
Iankelevich, D.E.; Tsarikovskaia, N.G.; Tkach, F.S.; Nikolaeva, V.M.; Langova, N.A. 1978: Glucocorticoid and androgenic functions of the adrenal cortex and the state of the sympathetic-adrenal system in thyrotoxicosis with primary organic disease of the central nervous system Problemy Endokrinologii 24(3): 22-27
Naumenko, E.V.; Shishkina, G.T. 1977: Participation of the cerebral serotonin receptors in the negative-feedback mechanisms of the hypothalamus-hypophysis-testis system Problemy Endokrinologii 23(2): 75-78
Garina, I.A.; Rakitskaia, V.V.; Shaliapina, V.G. 1990: The receptor binding of corticosterone in the monoaminergic structures of the rat brain after a neonatal block of the hypophysis-adrenal system Problemy Endokrinologii 36(5): 65-68
Schatz, H. 1982: Diseases of the endocrine organs during pregnancy. 2. Thyroid and adrenal cortex diseases Fortschritte der Medizin 100(38): 1753-1758
Krémers, P. 1973: Biochemical study of adrenal cortex 17-alpha-hydroxylase Archives Internationales de Physiologie et de Biochimie 81(2): 377-378
Hahn von Dorsche, H. 1984: Relations between the brain and the endocrine system from its chronobiological aspects. II. the hypophysis, adrenal gland, thyroid islet organ, gonads and kidney Anatomischer Anzeiger 155(1-5): 95-113
Angeli, A.; Boccuzzi, G.; Frairia, R.; Bisbocci, D. 1972: Behavior of the circadian rhythm of adrenal cortex secretion in anorexia nervosa in relation to the duration of amenorrhea Folia Endocrinologica 25(2): 153-160
Zieleniewski, W.; Zieleniewski, J.; Stepień, H. 1995: Interleukin-1 beta, but not IL-1 alpha, stimulates cell proliferation in the adrenal cortex Cytobios 84: 338-339
Akhmedov, N.A.; Popov, E.M. 1989: Structural organization of alpha-melanotropin molecules Molekuliarnaia Biologiia 23(1): 249-254
Bruhat, M. 1978: Dynamic testing of the hypothalamus and hypophysis controls Revue Francaise de Gynecologie et d'Obstetrique 73(4): 281-283
Takeda, R.; Tofuku, Y.; Takeda, Y. 1981: Adrenal cortex diseases and acid-base imbalance Nihon Rinsho. Japanese Journal of Clinical Medicine 39(11): 3513-3517
Slavnov, V.N.; Valueva, G.V.; Iakovlev, A.A.; Luchitskiĭ, E.V.; Iugrinov, O.G. 1982: Differential diagnosis of adrenal cortical tumors and hypothalamo-hypophyseo-adrenal system diseases Vrachebnoe Delo 10: 92-95